JMJD3 Antilichaam

JMJD3 Antibody: The Jumonji domain-containing protein 3 (JMJD3) functions as a trimethylation-specific demethylase, converting the trimethylated histone H3 Lys27 residue to the dimethylated form, and is thought to also function as a transcriptional repressor. JMJD3 plays a central role in regulation of posterior development, by regulating HOX gene expression. It is involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation. JMJD3 can also interact with and demethylate p53, resulting in its stabilization and localization to the nucleus in mouse embryo fibroblasts during neural stem cell differentiation.

23135

O15054

EAW90126

Human, Mouse, Rat

6657

Unconjugated

Primary Antibodies

Independent Antibody Validation in Cell lines (Figure 2) shows similar JMJD3 expression profile in human, mouse and rat cell lines detected by two independent anti-IFN-beta antibodies that recognize different epitopes, 6657 against C-terminus domain and 14-618 against N-terminus domain. IFN-beta proteins are detected in the most tested cell lines at different expression levels by the two independent antibodies. Independent Antibody Validation in Cell lines6657 14-618

Stem Cell

JMJD3 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1201 - HeLa Cell Lysate

1 mg/mL

JMJD3 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

JMJD3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

This antibody is specific for JMJD3 and will not recognize other JMJD proteins.

Human JMJD3 has 2 isoforms, including isoform 1 (1682aa, 181kD) and isoform 2 (1643aa, 177kD) . Mouse JMJD3 has one isoform (1641aa, 176kD) and rat JMJD3 also has one isoform (1356aa, 146kD) . 6657 can detect human, mouse and rat.

KDM6B

Cat. No. 17-004 - K-562 Cell Slide

Cat. No. 1204 - K562 Cell Lysate

Cat. No. 1288 - A-20 Cell Lysate

Lysine (K) -specific demethylase 6B

Homo sapiens

Agger et al. Nature 2007; 449:731-4.

De Santa et al. Cell 2007; 130:1083-94.

Sola et al. PLoS One 2011; 6:e18421.

JMJD3 Antibody: JMJD3, JMJD3, KIAA0346, Lysine-specific demethylase 6B, JmjC domain-containing protein 3

ELISA, WB, ICC, IF

122937251

Liquid