JP-2-196 (hydrochloride)
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
JP-2-196 hydrochloride is a covalent molecular glue degrader targeting RNF126. JP-2-196 hydrochloride induces the formation of a ternary complex between RNF126 and target proteins (e.g., BRD4, AR-V7), promoting their ubiquitination and proteasomal degradation. JP-2-196 hydrochloride is promising for research of cancers (e.g., prostate cancer, leukemia) [1].
12352005
E1/E2/E3 Enzyme; Molecular Glues
Metabolic Enzyme/Protease; PROTAC
Cancer
O=C(C1=CC=C(OC)C=C1)/C=C/C(N2CCNCC2)=O.Cl
C15H19ClN2O3
310.78
[1]Toriki ES, et al. Rational Chemical Design of Molecular Glue Degraders. ACS Cent Sci. 2023 Apr 11;9 (5) :915-926.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-W854844B/
Reference compound1
No Development Reported
Beschrijving
JP-2-196 hydrochloride is a covalent molecular glue degrader targeting RNF126. JP-2-196 hydrochloride induces the formation of a ternary complex between RNF126
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