JTV-506
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
JTV-506 is a potent ATP-sensitive potassium channel opener. JTV-506 inhibits Histamine -induced contraction of tracheal smooth muscle by activation of KATP channels. JTV-506 attenuates pulmonary vascular tone through its direct action on vascular smooth muscle cells. JTV-506 can be used for pulmonary hypertension research[1][2].
170148-29-5
12352005
Potassium Channel
Membrane Transporter/Ion Channel
Cardiovascular Disease
N#CC1=CC=C2C([C@@H](NC(C=C3)=NN(C)C3=O)[C@H](O)C(COC)(COC)O2)=C1
C19H22N4O5
386.40
[1]Ando T, et al. Effects of JTV-506, a new K+ channel activator, on airway smooth muscle contraction and systemic blood pressure. Clin Exp Allergy. 1997 Jun;27 (6) :705-13.|[2]Tsutsumi Y, et al. JTV-506, a new K (ATP) channel opener, relaxes pulmonary artery isolated from monocrotaline-treated pulmonary hypertensive rats. J Anesth. 2004;18 (3) :210-5.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-19244/
Reference compound1
Phase 2
Beschrijving
JTV-506 is a potent ATP-sensitive potassium channel opener. JTV-506 inhibits Histamine -induced contraction of tracheal smooth muscle by activation of KATP chan
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