Kaliumkanaalantilichaam

Voltage-gated K+ channels are important determinants of neuronal membrane excitability, and differences in K+ channel expression patterns and densities contribute to the variations in action potential waveforms and repetitive firing patterns evident in different neuronal cell types. The delayed rectifier-type (IK) channels (Kv1.5, Kv2.1, and Kv2.2) are expressed on all neuronal somata and proximal dendrites and are also found in a wide variety on non-neuronal cells types including pancreatic islets, alveolar cells and cardiac myocytes. Kv2.1 and Kv2.2 form distinct populations of K+ channels and these subunits are thought to be primarily responsible for IK in superior cervical ganglion cells.

117105

Q63099

Q63099

Rat, Frog

Potassium Channel, Kv2.

Unconjugated

Primary Antibodies

Signal Transduction, Neuroscience

Affinity Purified

Batch dependent

None

Blue Ice

Potassium Channel, Kv2.2 Subunit antibody can be stored at -20˚ C. After reconstitution in 50 μ l PBS, the antibody should be aliquot and stored at -20˚ C and is stable at -20˚ C for at least 1 year. Ambient shipment is suitable for both international and domestic.

100

Potassium Channel antibody can be used for specific immunolabeling of the ~125k Kv 2.2 protein in Western blots. Applications include Dot Blots (DB), Immunohistochemistry (IHC) and Western Blots (WB) . Rabbit anti-Potassium Channel, Kv2.2 recognizes Kv2.2 in rat and Xenopus. When internally tested under ideal conditions the working dilutions were 1:1000 for IHC, DB and WB.

Kcnb2

Potassium voltage gated channel, Shab-related subfamily, member 2

Rattus norvegicus

Burger, C. and Ribera, A.B. "Xenopus spinal neurons express Kv2 potassium channel transcripts during embryonic development, " J Neurosci. 16 (1996) 1412 - 1421.

Pongs, O. "Voltage-gated potassium channels: from hyperexcitability to excitement, " FEBS Lett. 452 (1999) 31-35.

Maletic-Savatic, M., Lenn, N.J., and Trimmer, J.S. "Differential spatiotemporal expression of K+ channel polypeptides in rat hippocampal neurons developing in situ and in vitro, " J Neurosci. 15 (1995) 3840-3851.

Hwang, P.M., Fotuhi, M., Bredt, D.S., Cunningham, A.M., and Snyder, S.H. "Contrasting immunohistochemical localizations in rat brain of two novel K+ channels of the Shab subfamily, " J. Neurosci., 13 (1993) 1569 - 1576.

WB, IHC

24418850

Liquid