Kank1 Antilichaam

KANK1 Antibody: Ankyrins are membrane adaptor molecules that play important roles in the control of cytoskeleton formation by regulating actin polymerization. KANK1 (KN motif and ankyrin repeat domain-containing protein 1), also known as ANKRD15, is a 1,352 amino acid protein that contains at least 12 exons and 5 ANK repeats. It binds to beta-catenin and regulates its subcellular distribution. KANK1 is ubiquitously expressed and localizes to cytoplasm. It may function as a tumor suppressor for renal cell carcinoma. Mutations in this gene cause cerebral palsy spastic quadriplegic type 2, a central nervous system development disorder.

23189

Q14678

NP_055973

Human, Mouse

Unconjugated

Primary Antibodies

Cancer, Cell Cycle

KANK1 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1282 - 3T3 (NIH) Cell Lysate

1 mg/mL

KANK1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

KANK1 antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.

IgG

Two alternatively spliced transcript variants encoding different isoforms have been identified. The lower molecular weight band seen in the immunoblot is thought to be non-specific.

KANK1

Cat. No. 10-401 - Human Kidney Tissue Slide

KN motif and ankyrin repeat domains 1

Homo sapiens

Zhu Y, Kakinuma N, Wang Y, et al. Kank proteins: a new family of ankyrin-repeat domain containing proteins. Biochim. Biophys. Acta 2008; 1780:128-33.

Roy BC, Kakinuma N, Kiyama R. Kank attenuates actin remodeling by preventing interaction between IRSp53 and Rac1. J. Cell Biol. 2009; 184:253-67.

Sarkar S, Roy BC, Hatano N, et al. A novel ankyrin repeat-containing gene (Kank) located at 9p24 is a growth suppressor of renal cell carcinoma. J. Biol. Chem. 2002; 277:36585-91.

Lerer I, Sagi M, Meiner V, et al. Deletion of the ANKRD15 gene at 9p24.3 causes parent-of-origin-dependent inheritance of familial cerebral palsy. Hum. Mol. Genet. 2005; 14: 3911-20

KANK1 Antibody: KANK, CPSQ2, ANKRD15, KANK, KIAA0172, KN motif and ankyrin repeat domain-containing protein 1, Ankyrin repeat domain-containing protein 15

ELISA, WB, IHC-P, IF

64464726

Liquid