KappaB race 2 Antilichaam

KappaB ras2 Antibody: KappaB ras-1 (κ B-ras-1) and kappaB-ras-2 are two small proteins that similar to Ras-like small GTPases that associate with Iκ B (Iκ B), an inhibitor of the transcription factor NF-κ B. Iκ B exists in two homologous forms, Iκ B-alpha and Iκ B-beta, although Iκ B-beta contains a unique 47-amino acid region within its ankyrin domain. While inactive Iκ B-alpha-NF-κ B complexes can shuttle in and out of the nucleus, Iκ B-beta-NF-κ B complexes are retained exclusively in the cytoplasm. It is suggested that kappaB-ras proteins preferentially bind to the Iκ B-beta form through this unique insert within the ankyrin region, thus modulating the cellular location of Iκ B-beta and regulating the rate of degradation of Iκ B-beta. This antibody is specific for kappaB-ras2 and has no cross-reactivity to kappaB-ras1.

28511

Q9NYR9

NP_060065

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Signal Transduction

KappaB ras2 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1283 - RAW 264.7 Cell Lysate

1 mg/ml

Predicted species reactivity based on immunogen sequence: Chicken: (93%)

KappaB ras2 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

KappaB ras2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

NKIRAS2

NFKB inhibitor interacting Ras-like 2

Homo sapiens

Fenwick C, Na SY, Voll RE, et al. A subclass of Ras proteins that regulate the degradation of IkappaB. Science 2000; 287:869-73.

Chen Y, Wu J and Ghosh G. KappaB-Ras binds to the unique insert within the ankyrin repeat domain if IkappaBbeta and regulates cytoplasmic retention of IkappaBbeta x NF-kappaB complexes. J. Biol. Chem.2003; 278:23101-6.

KappaB ras2 Antibody: KBRAS2, kappaB-Ras2, KBRAS2, NF-kappa-B inhibitor-interacting Ras-like protein 2, I-kappa-B-interacting Ras-like protein 2, Kappa B-Ras protein 2

ELISA, WB

19072794

Liquid