KChIP3 Antilichaam, Kloon X12: RPE

KChIP3, also known as DREAM or calsenilin, is a neuronal calcium-binding protein that plays a central role in regulating gene expression, potassium channel activity, and neurodegenerative signaling. It modulates Kv4 potassium channels, thereby influencing neuronal excitability and synaptic plasticity, which are key processes disrupted in neurodegenerative diseases such as Alzheimer’s. In the nucleus, KChIP3 acts as a calcium-dependent transcriptional repressor, regulating genes like prodynorphin that are involved in pain signaling and neuroprotection. Its interaction with presenilin proteins affects amyloid precursor protein processing, linking KChIP3 to Alzheimer’s disease pathology. Our recombinant monoclonal antibody targeting rat KChIP3 has been shown to enable high-specificity detection in rodent brain lysates and in overexpression lysates

Rabbit Anti-Rat KChIP3 Recombinant Monoclonal IgG Kappa

KChIP3 Antibody, Kv channel-interacting protein 3 Antibody, Kcnip3 Antibody, A-type potassium channel modulatory protein 3 Antibody, Calsenilin Antibody, Csen Antibody, DRE-agonist modulator Antibody, Dream Antibody

12352203

Non-hazardous

Non-hazardous

65199

Q9JM47

NP_115851.1

Fusion protein, AA #1-256 (full length) of rat KChIP3.

X12

RPE

Brain

Recombinant Monoclonal

WB

Neuroscience | Ion Channels | Potassium Channels | Voltage-Gated Potassium Channel-Interacting Proteins | Cell Signaling | Cardiovascular System | Blood

AmMagTM Ultra AT Protein A MagBeads

1 µg/ml was sufficient for detection of KChIP3 on Rat Brain Membrane lysate.

1mg/mL

WB (1:1000) ; optimal dilutions for assays should be determined by the user.

95.46mM Phosphate, 2.48mM MES and 2mM EDTA

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Blue Ice or 4ºC

Conjugated antibodies should be stored according to the product label

https://www.stressmarq.com/wp-content/uploads/Antibody-MSDS.pdf

Detects full length KChIP3. Does not cross-react with KChiP1, KChiP2, or KChiP4.

1. Wang, S. et al. (2002) . Kinetic properties of Kv4.3 and their modulation by KChIP2b. Biochem Biophys Res Commun, 295 (2), 223-229. https://doi.org/10.1016/S0006-291X (02) 00658-7 2. Van Vickle, G.D., Esh, C.L., Kokjohn, T.A. et al. Presenilin-1 280Glu→Ala Mutation Alters C-Terminal APP Processing Yielding Longer Aβ Peptides: Implications for Alzheimer’s Disease. Mol Med 14, 184–194 (2008) . https://doi.org/10.2119/2007-00094.VanVickle 3. Zaidi, N. F., Kuplast, K. G., Washicosky, K. J., Kajiwara, Y., Buxbaum, J. D., & Wasco, W. (2006) . Calsenilin interacts with transcriptional co-repressor C-terminal binding protein (s) . Journal of neurochemistry, 98 (4), 1290–1301. https://doi.org/10.1111/j.1471-4159.2006.03972.x

Human | Mouse | Rat

Cytoplasm, Cell membrane, Endoplasmic reticulum, Golgi apparatus, Nucleus

IgG Kappa

Rat