KCNK1 Antilichaam

The potassium channel, subfamily K, member 1 (KCNK1), is member of the superfamily of potassium channel proteins containing two pore-forming P domains (1,2) . KCNK1 is a ubiquitous human weakly inward rectifying K+ channel that is widely expressed in human tissues, and particularly abundant in brain and heart (1) . Both KCNK1 and the related protein KCNK2 contribute significantly to the passive conductance of hippocampal astrocytes (3) .

3775

O00180

NP_002236

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Neuroscience

KCNK1 antibody is affinity chromatography purified via peptide column.

Cat. No. 1212 - 3T3 Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Rabbit: (100%), Bovine: (100%), Guinea pig: (100%)

KCNK1 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

KCNK1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

KCNK1 antibody is human, mouse and rat reactive. KCNK1 antibody is predicted to not cross-react with other KCNK proteins.

KCNK1

Potassium channel, subfamily K, member 1

Homo sapiens

Lesage F, Guillemare E, Fink M, et al. TWIK-1, a ubiquitous human weakly inward rectifying K+ channel with a novel structure. EMBO J. 1996; 15:1004-11.

Goldstein SA, Bockenhauer D, O'Kelly I, et al. Potassium leak channels and the KCNK family of two-P domain subunits. Nat. Rev. Neurosci. 2001; 2:175-84.

Zhou M, Xu G, Xie M, et al. TWIK-1 and TREK-2 are potassium channels contributing significantly to astrocyte passive conductance in rat hippocampal slides. J. Neurosci. 2009; 29:8551-64.

Potassium channel subfamily K member 1, DPK, HOHO, K2P1, K2p1.1, KCNO1, TWIK-1, TWIK1

ELISA, WB, IHC-P, IF

4504847

Liquid