KCNK12 Antilichaam

KCNK12 Antibody: KCNK13 and KCNK12 (also known as THIK1 and 2) are the first two members of a novel two pore-forming P domains K+ channels subfamily. The pore loop domain, a highly conserved region common to all potassium channels, is involved in determining potassium ion selectivity. Members of this family are all characterized by four transmembrane domains and may function to help influence the resting membrane potential of cells. KCNK12 is expressed mainly in the brain and lung, but also observed in the kidneys, heart and skeletal muscle. KCNK12 is closely related to KCNK13 (58% identity at the amino acid level), but could not yet been functionally expressed in vitro and may require other proteins to become active.

56660

Q9HB15

NP_071338

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Signal Transduction

KCNK12 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1463 - Rat Brain Tissue Lysate

1 mg/mL

KCNK12 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

KCNK12 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

KCNK12 antibody is predicted to not cross-react with other KCNK protein family members.

KCNK12

Potassium channel, subfamily K, member 12

Homo sapiens

Rajan S, Wischmeyer E, Karschin C, et al. THIK-1 and THIK-2, a novel subfamily of tandem pore domain K+ channels. J. Biol. Chem. 2001; 276:7302-11

Jezzini SH and Moroz LL. Identification and distribution of a twopore domain potassium channel in the CNS of Aplysia californica. Brain Res. Mol. Brain Res. 2004; 127:27-38

Theilig F, Goranova I, Hirsch JR, et al. Cellular localization of THIK-1 (K (2P) 13.1) and THIK-2 (K (2P) 12.1) K channels in the mammalian kidney. Cell Physiol. Biochem. 2008; 21:63-74.

Girard C, Duprat F, Terrenoire C, et al. Genomic and functional characteristics of novel human pancreatic 2P domain K+ channels. Biochem. Biophys. Res. Commun. 2001; 282:249-56.

KCNK12 Antibody: THIK2, THIK-2, K2p12.1, Potassium channel subfamily K member 12, Tandem pore domain halothane-inhibited potassium channel 2

ELISA, WB, IHC-P, IF

11545761

Liquid