KCNK13 Antilichaam

KCNK13 Antibody: The closely related proteins KCNK13 and KCNK12 (also known as THIK1 and 2) are the first two members of a novel two pore-forming P domains K+ channels subfamily. The pore loop domain, a highly conserved region common to all potassium channels, is involved in determining potassium ion selectivity. Members of this family are all characterized by four transmembrane domains and may function to help influence the resting membrane potential of cells. KCNK13 is expressed mainly in the brain, but is also observed in kidneys. KCNK13 has been suggested to be a candidate for the Cs+-permeable K+ channel activated by GABA (B) receptors.

56659

Q9HB14

NP_071337

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Signal Transduction

KCNK13 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1463 - Rat Brain Tissue Lysate

1 mg/mL

KCNK13 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

KCNK13 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

KCNK13 antibody is predicted to not cross-react with other KCNK protein family members.

KCNK13

Cat. No. 10-301 - Human Brain Tissue Slide

Potassium channel, subfamily K, member 13

Homo sapiens

Rajan S, Wischmeyer E, Karschin C, et al. THIK-1 and THIK-2, a novel subfamily of tandem pore domain K+ channels. J. Biol. Chem. 2001; 276:7302-11.

Jezzini SH and Moroz LL. Identification and distribution of a twopore domain potassium channel in the CNS of Aplysia californica. Brain Res. Mol. Brain Res. 2004; 127:27-38.

Theilig F, Goranova I, Hirsch JR, et al. Cellular localization of THIK-1 (K (2P) 13.1) and THIK-2 (K (2P) 12.1) K channels in the mammalian kidney. Cell Physiol. Biochem. 2008; 21:63-74

Ishii H, Nakajo K, Yanagawa Y, et al. Identification and characterization of Cs (+) -permeable K (+) channel current in mouse cerebellar Purkinje cells in lobules 9 and 10 evoked by molecular layer stimulation. Eur. J. Neurosci. 2010; 32:736-48

KCNK13 Antibody: THIK1, THIK-1, K2p13.1, Potassium channel subfamily K member 13, Tandem pore domain halothane-inhibited potassium channel 1

ELISA, WB, IHC-P, IF

16306555

Liquid