KCNMB3 (NM 171828) Humaan Recombinant Proteïne

MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which may partially inactivate or slightly decrease the activation time of MaxiK alpha subunit currents. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 22. [provided by RefSeq, Jul 2009]

Purified recombinant protein of Human potassium large conductance calcium-activated channel, subfamily M beta member 3 (KCNMB3), transcript variant 1, Gln87-Gln205, with N-terminal His-Trx tag, expressed in E. coli, 50ug

BKBETA3; HBETA3; K (VCA) BETA-3; KCNMB2; KCNMBL; SLO-BETA-3; SLOBETA3

27094

Q9NPA1

NM_171828

3q26.32

E. coli

N-His-Trx

Vascular smooth muscle contraction

Vascular smooth muscle contraction

>50 ug/mL as determined by microplate BCA method

> 80% as determined by SDS-PAGE and Coomassie blue staining

Liquid

25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol.

Druggable Genome, Ion Channels: Other, Transmembrane

34.1 kDa

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

KCNMB3

Human

NP_741979

https://www.ncbi.nlm.nih.gov/gene/27094

https://www.uniprot.org/uniprot/Q9NPA1

https://www.ncbi.nlm.nih.gov/nuccore/NM_171828

https://www.ncbi.nlm.nih.gov/nuccore/NP_741979