KCNN3 Antilichaam - C-terminal regio : HRP (ARP35097 P050-HRP)

Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3

SK3, ZLS3, hSK3, SKCA3, KCa2.3

3782

Q9UGI6

NP_002240

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

The immunogen is a synthetic peptide directed towards the C terminal region of human KCNN3

Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. KCNN3, a member of the KCNN family of potassium channel genes, encodes a protein that is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits.

UBC; RAB5A; DNM2; CAV1; APP; CALM1

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB, IHC

Affinity Purified

KCNN3 is supported by BioGPS gene expression data to be expressed in Daudi

0.5 mg/ml

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

81kDa

Kolski-Andreaco, A., et al., (2004) J. Biol. Chem. 279 (8), 6893-6904

Wet Ice

736

KCNN3

KCNN3

Rabbit

Small conductance calcium-activated potassium channel protein 3

NM_002249

ITELNDRSEDLEKQIGSLESKLEHLTASFNSLPLLIADTLRQQQQQLLSA