KDM1B Antilichaam

Flavin-dependent histone demethylases regulate histone lysine methylation, an epigenetic mark that regulates gene expression and chromatin function (reviewed in 1) . KDM1B is a recently identified histone H3K4 demethylase that is required to establish maternal genomic imprints; targeted disruption of the KDM1B gene in mice led to lethality in their embryos, suggesting demethylation of H3K4 is critical for establishing the DNA methylation imprints (2) . KDM1B has also been shown to play a role in the transcription elongation in several genes (3) .

221656

Q8NB78

NP_694587

Human, Mouse

Unconjugated

Primary Antibodies

Homeostasis

KDM1B antibody is affinity chromatography purified via peptide column.

Cat. No. 1204 - K562 Cell Lysate

1 mg/mL

KDM1B antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

KDM1B antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

KDM1B antibody is human, mouse and rat reactive. At least two isoforms of KDM1B are known to exist; this KDM1B antibody will detect both isoforms.

KDM1B

Lysine (K) -specific demethylase 1B

Homo sapiens

Culhane JC and Cole PA. LSD1 and the chemistry of histone demethylation. Curr. Opin. Chem. Biol. 2007; 11:561-8.

Ciccone DN, Su H, Hevi S, et al. KDM1B is a histone H3K4 demethylase required to establish maternal genomic imprints. Nature 2009; 461:415-8.

Fang R, Barbera A, Xu Y, et al. Human LSD2/KDM1b/AOF1 regulates genes transcription by modulating intragenic H3K4me2 methylation. Mol. Cell 2010; 39:222-233.

KDM1B Antibody: AOF1, LSD2, C6orf193, bA204B7.3, dJ298J15.2, AOF1, Lysine-specific histone demethylase 1B, Flavin-containing amine oxidase domain-containing protein 1

ELISA, WB

116256451

Liquid