Keratine 8 (Ab 74)

Keratin 8 is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis.

3856

P05787

NP_002264.1

Human

Keratin 8 (Ab-74) antibody was raised against a peptide sequence around aa.72~76 (L-L-S-P-L) derived from Human Keratin 8 (CK8) .

Unconjugated

Primary Antibodies

Other

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

None

Blue Ice

Store antibody at -20˚ C for up to one year.

55 kDa

This antibody detects endogenous level of total Keratin 8 protein.

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200

KRT8

Keratin 8

Homo sapiens

Nakamichi I, et al. (2002) Mol Biol Cell; 13 (10) : 3441-3451. Prochasson P, et al. (2002) Nucleic Acids Res; 30 (15) : 3312-3322. Pankov R, et al. (1994) Proc Natl Acad Sci U S A; 91 (3) : 873-877. Thorey IS, et al. (1993) Mol Cell Biol; 13 (11) : 6742-6751.

K8, KO, CK8, CK-8, CYK8, K2C8, CARD2, HSTF1, CK 8, Cytokeratin endo A, K8

WB, IHC, IF

4504919

Liquid