Ketoprofeen-13C6

Ketoprofen-13C6 (RP-19583-13C6) is 13C labeled Ketoprofen. Ketoprofen (RP-19583) is a non-steroidal anti-inflammatory agent. Ketoprofen can inhibits the activity of cyclooxygenase with IC50 values of 2 nM (COX-1) and 26 nM (COX-2) . which is potential in the research of inflammation, immunology, and metabolic disease such as obesity[1][2][3].

1261392-46-4

RP-19583-13C6

12352005

COX; Isotope-Labeled Compounds

Immunology/Inflammation; Others

Metabolism-protein/nucleotide metabolism

Metabolic Disease; Inflammation/Immunology; Cancer

O=C([13C]1=[13CH][13CH]=[13CH][13CH]=[13CH]1)C2=CC(C(C)C(O)=O)=CC=C2

C10 13C6H14O3

260.24

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Palomer A, et al. Structure-based design of cyclooxygenase-2 selectivity into ketoprofen. Bioorg Med Chem Lett. 2002 Feb 25;12 (4) :533-7. |[3]NamHyeon Kang Ketoprofen alleviates diet-induced obesity and promotes white fat browning in mice via the activation of COX-2 through mTORC1-p38 signaling pathway. Pflugers Arch. 2020 May;472 (5) :583-596. |[4]Denisa Dan, et al. Ketoprofen affects the mammary immune response in dairy cows in vivo and in vitro. J Dairy Sci. 2018 Dec;101 (12) :11321-11329.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-B0227S3/

Isotope-Labeled Compounds

No Development Reported