KHDC1 Antilichaam

KHDC1 Antibody: KHDC1 family members are K-homology (KH) domain-containing RNA binding proteins that are involved in various aspects of RNA metabolism, ranging from transcription to RNA splicing, transportation, translation, and stability (1) . KHDC1 is highly expressed in oocytes and interacts with cytoplasmic polyadenylation element-binding protein 1 (CPEB1), a key translational regulator controlling the polyA length of mRNAs (2,3) . KHDC1 functions as a global translational repressor and induces apoptosis through an ER-dependent signaling pathway and that the C-terminal putative trans-membrane motif (TMM) is critical for its activities (3,4) .

80759

Q4VXA5

NP_085045

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Apoptosis

KHDC1 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1464 - Rat Liver Tissue Lysate

1 mg/mL

KHDC1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

KHDC1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Probable post-translational modification

IgG

KHDC1 antibody is human, mouse and rat reactive. At least three isoforms of KHDC1 are known to exist; this antibody will only detect the longest isoform.

KHDC1

Cat. No. 10-201 - Human Liver Tissue Slide

KH homology domain containing 1

Homo sapiens

Valverde R, Edwards L, and Regan L. Structure and function of KH domains. FEBS J. 2008; 275:2712–26.

Pierre A, Gautier M, Callebaut I, et al. Atypical structure and phylogenomic evolution of the new eutherian oocyte- and embryo-expressed KHDC1/DPPA5/ECAT1/OOEP gene family. Genomics 2007; 90:583-94.

Cai C, Liu J, Wang C, et al. KHDC1A, a novel translational repressor, induces endoplasmic reticulum-dependent apoptosis. DNA Cell Biol. 2012; 31:1447-57.

KHDC1 Antibody: NDG1, C6orf148, bA257K9.4, KH homology domain-containing protein 1

ELISA, WB, IHC-P

117956389

Liquid