KIR2DS2 Antilichaam

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells (1) . The KIR proteins are classified by the number of extracellular immunoglobulin domains and by whether they have a long (L) or short (S) cytoplasmic domain (2,3) . KIR proteins are thought to play an important role in regulation of the immune response (3) . KIR2DS2 downregulates the cytotoxicity of NK cells upon recognition of specific class I major histocompatibility complex (MHC) molecules on target cells and is a receptor on natural killer (NK) cells for HLA-C alleles (3,4) .

100132285

P43631

NP_036444

Human

Unconjugated

Primary Antibodies

Immunology

KIR2DS2 antibody is affinity chromatography purified via peptide column.

Cat. No. 1210 - HEK293 Cell Lysate

1 mg/mL

KIR2DS2 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

KIR2DS2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Potentially post-translationally modified

IgG

KIR2DS2 antibody is human specific. Multiple isoforms are known to exist.

KIR2DS2

Cat. No. 17-010 - HEK293 Cell Slide

Killer cell immunoglobulin-like receptor two domains short cytoplasmic tail 2

Homo sapiens

Colonna M and Samaridis J. Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells. Science 1995; 268:405-8.

Biassoni R, Cantoni C, Falco M, et al. The human leukocyte antigen (HLA) -C-specific "activatory" or "inhibitory" natural killer cell receptors display highly homologous extracellular domains but differ in their transmembrane and intracytoplasmic portions. J. Exp. Med. 1996; 183:645-50.

Wagtmann N, Biassoni R, Cantoni C, et al. Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains. Immunity 1995; 2:439-49.

Moesta AK and Parham P. Diverse functionality among human NK cell receptors for the C1 epitope of HLA-C: KIR2DS2, KIR2DL2, and KIR2DL3. Front. Immunol. 2012; 3:336.

Killer cell immunoglobulin-like receptor two domains short cytoplasmic tail 2, KIR2DL3, MHC class I NK cell receptor, Natural killer-associated transcript 5, NKAT5, p58 KIR, p58 natural killer cell receptor clone CL-49, p58 NK receptor

ELISA, WB, IF, ICC

6912472

Liquid