KIRREL2 Antilichaam

KIRREL2, also known as nephrin-like 3, is a type I transmembrane protein belonging to the immunoglobulin superfamily of cell adhesion molecules (1) . KIRREL2 consists of five extracellular Ig-like repeats, a transmembrane domain, several glycosylation sites and a cytoplasmic domain that has a stretch of nine conserved residues (1,2) . KIRREL2 has been found to be expressed in beta cells of pancreatic islets and is involved in the regulation of both glomerular and neural development (3,4) . Downregulation of KIRREL2 is implicated in several proteinuric diseases (4,5) .

84063

Q6UWL6

NP_954649

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Neuroscience, Stem Cell

KIRREL2 antibody is affinity chromatography purified via peptide column.

Cat. No. 1210 - HEK293 Cell Lysate

1 mg/mL

KIRREL2 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

KIRREL2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

KIRREL2 antibody is human, mouse and rat reactive. At least five isoforms are are known to exist. This antibody is predicted to not cross-react with other members of the KIRREL protein family.

KIRREL2

Cat. No. 11-101 - Human Pancreas Tissue Slide

Kin of IRRE like 2 (Drosophila)

Homo sapiens

Sun C, Kilburn D, Lukashin A, et al. KIRREL2, a novel immunoglobulin superfamily gene expressed primarily in beta cells of the pancreatic islets. Genomics 2003; 82:130-42.

Heikkila E, Ristola M, Havana M, et al. Trans-interaction of nephrin and Neph1/Neph3 induces cell adhesion that associates with decreased tyrosine phosphorylation of nephrin. Biochem. J. 2011; 435:619-28.

Wang H, Lehtonen S, Chen YC, et al. Neph3 associates with regulation of glomerular and neural development in zebrafish. Differentiation 2012; 83:38-46.

Mizuhara E, Minaki Y, Nakatani T, et al. Purkinje cells originate from cerebellar ventricular zone progenitors positive for Neph3 and E-cadherin. Dev. Biol. 2010; 338:202-14.

Kin of irregular chiasm-like protein 2, Kin of IRRE-like protein 2, NEPH3, Nephrin-like protein 3, NLG1, FILTRIN

ELISA, WB, IHC-P, IF

145275174

Liquid