Kisspeptineantagonist p271

Kisspeptin antagonist p271 is a Kisspeptin antagonist with cell-penetrating ability. Kisspeptin antagonist p271 can block the binding of endogenous Kisspeptin to GPR54 on pituitary somatotropes, thereby relieving the inhibition of growth hormone secretion. Kisspeptin antagonist p271 can specifically and significantly stimulate growth hormone secretion, while inhibiting luteinizing hormone without affecting prolactin or cortisol. Kisspeptin antagonist p271 can be used in the research of diseases related to insufficient growth hormone secretion[1].

12352209

Kisspeptin Receptor

GPCR/G Protein

Metabolism-protein/nucleotide metabolism

Endocrinology

99.76

DMSO : 50 mg/mL (ultrasonic)

O=C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCSC)C(N[C@@H](CCCCN)C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CC3=CC=C(C=C3)O)C(N[C@H](C)C(N[C@@H](CC(N)=O)C(N[C@@H](CC4=CNC5=CC=CC=C45)C(N[C@@H](CC(N)=O)C(NCC(N[C@@H](CC6=CC=CC=C6)C(NCC(N[C@H](CC7=CNC8=CC=CC=C78)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC9=CC=CC=C9)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCNC(N)=N)N

C116H164N36O21S

2430.84

[1]Smith JT, et al. Stimulation of growth hormone by kisspeptin antagonists in ewes. J Endocrinol. 2018 May;237 (2) :165-173.

Blue Ice

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

http://file.medchemexpress.com/batch_PDF/HY-P11341/Kisspeptin-antagonist-p271-SDS-MedChemExpress.pdf

Peptides

No Development Reported