KLA-peptide (acetaat)

KLA peptide acetate a cationic amphipathic mitochondrial membrane disrupting peptide that induces cell apoptosis by disrupting mitochondrial membrane. KLA peptide acetate can be used for the researches of cancer, inflammation, and neurological disease[1][2].

12352209

Apoptosis

Apoptosis

COVID-19-immunoregulation

Cancer; Inflammation/Immunology; Neurological Disease

99.81

H2O : ≥ 100 mg/mL

O=C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N[C@@H](CCCCN)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCCN)N.CC(O)=O.[x]

C72H138N20O15.xC2H4O2

1523.99 (free base)

[1]Guo Z, et al. Specific hepatic stellate cell-penetrating peptide targeted delivery of a KLA peptide reduces collagen accumulation by inducing apoptosis. J Drug Target. 2017 Sep;25 (8) :715-723.|[2]Zen R, et al. Pro-inflammatory microglia-targeted peptide therapy ameliorates neonatal hypoxic-ischemic encephalopathy in mice. Mol Ther. 2025 Jul 2;33 (7) :3177-3194.

Blue Ice

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

http://file.medchemexpress.com/batch_PDF/HY-P5345A/KLA-peptide-acetate-SDS-MedChemExpress.pdf

Peptides

No Development Reported