KLB Polyklonale Antilichaam, PerCP Vervoeging
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
BetaKlotho is a 1044 amino acid single-pass type III membrane protein that plays a key role in bile acid and cholesterol metabolism by suppressing transcription of CYP7A1 (cholesterol 7-alpha-hydroxylase), the rate-limiting enzyme in bile acid synthesis. Homozygous negative betaKlotho mice showed dramatically elevated bile acid synthesis and secretion, as well as a strong upregulation of CYP7A1 and CYP8B1 and resistance to gallstone formation. FGF19 and FGF21 require direct interaction with betaKlotho for activation, intracellular signaling and gene expression modulation. Both Klotho and betaKlotho consist of two internal repeats similar to family 1 glycosidases. BetaKlotho contains two glycosyl hydrolase 1 regions, however since these regions lack essential glutamic acid residues at specific and crucial locations, the domains appear to be inactive.
Beta-klotho; BetaKlotho; BKL; KLB; KLOTB_HUMAN; Klotho beta like protein; Klotho beta-like protein.
152831
Q86Z14
• Rabbit
Human
451-550/1044
KLB
• Polyclonal
• IgG
PerCP
KLH conjugated synthetic peptide derived from human KLB
WB, IF
Purified by Protein A.
482nm/677nm
1µg/µl
WB (WB=1:500-2000), IF (IF=1:100-500)
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Unmodified
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
152831
Beschrijving
KLB Polyklonale Antilichaam, PerCP Vervoeging Beschikbaar in 100 µL. Bestel eenvoudig online met snelle levering.
Specificaties
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