KLF17 Antilichaam

KLF17, also known as ZNF393, is a member of the Sp/KLF family of transcription factors (1,2) . KLF17 binds to the promoter and negatively regulates the transcription of Id-1, a key metastasis regulator in breast cancer (3) . Suppression of KLF17 promotes breast cancer cell invasion and epithelial-mesenchymal transition (3) . Down-regulated KLF17 expression is also associated tumor invasion and poor prognosis in hepatocellular carcinoma, suggesting that the level of KLF17 expression can serve as a prognostic indicator (4) .

128209

Q5JT82

NP_775755

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Cancer

KLF17 antibody is affinity chromatography purified via peptide column.

Cat. No. 1464 - Rat Liver Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Pig: (81%), Chicken: (79%)

KLF17 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

KLF17 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

KLF17 antibody is human, mouse and rat reactive. At least two isoforms of KLF17 are known to exist; this antibody will only detect the large isoform. KLF17 antibody is predicted to not cross-react with other KLF proteins.

KLF17

Kruppel-like factor 17

Homo sapiens

Yan W, Burns KH, Ma L, et al. Identification of Zfp393, a germ cell-specific gene encoding a novel zinc finger protein. Mech. Dev. 2002; 118:233-9.

Van Vliet J, Crofts LA, Quinlan KG, et al. Human KLF17 is a new member of the Sp/KLF family of transcription factors. Genomics 2006; 87:474-82.

Gumireddy K, Li A, Gimotty PA, et al. KLF17 is a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Nat. Cell Biol. 2009; 11:1297-304.

Liu FY, Deng YL, Li Y, et al. Down-regulated KLF17 expression is associated with tumor invasion and poor prognosis in hepatocellular carcinoma. Med. Oncol. 2013; 30:425.

Kruppel-like factor 17, zinc finger protein 393, ZNF393, Zfp393

ELISA, WB, IHC-P

104294874

Liquid