KLHL1 Antilichaam

KLHL1 Antibody: The mammalian Kelch-like 1 (KLHL1) was initially discovered as a homolog to the Drosophila Kelch gene that is highly expressed in several brain tissues. The predicted protein domain structure of KLHL1 is characteristic of a number of proteins that bind actin, form dimers, and often act as actin-organizing proteins. Based on the presence of anti-sense RNA that spans the transcription and translation start sites as well as the first splice site of KLHL1 in brain tissue of individuals suffering from the neurodegenerative disorder spinocerebellar ataxia type 8 (SCA8), it has been suggested that KLHL1 is involved this disease and that regulation of KLHL1 protein may be affected by antisense RNA expression.

57626

Q9NR64

AAF81719

Human, Rat

Unconjugated

Primary Antibodies

Neuroscience

KLHL1 Antibody is immunoaffinity purified .

Cat. No. 1201 - HeLa Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Mouse: (100%)

KLHL1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

KLHL1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

KLHL1

Cat. No. 1403 - Mouse Brain Tissue Lysate

Kelch-like 1 (Drosophila)

Homo sapiens

Nemes JP, Benzo KA, and Koob MD. The SCA8 transcript is an antisense RNA to a brain-specific transcript encoding a novel actin-binding protein (KLHL1) . Human Mol. Gen. 2000; 9:1543-51.

Adams J, Kelso R, and Cooley L. The kelch repeat superfamily of proteins: propellers of cell function. Trends Cell Biol. 2000; 10:17-24.

Robinson DN and Cooley L. Drosophila kelch is an oligomeric ring canal actin organizer. J. Cell Biol. 1997; 138:799-810.

KLHL1 Antibody: MRP2, KIAA1490, Kelch-like protein 1

ELISA, WB, IHC-P

8926179

Liquid