KMT5C Antilichaam / SUV420H2

KMT5C, also called Suppressor of variegation 4-20 homolog 2, Su (var) 4-20 homolog 2 and Suv4-20h2, belongs to a family of proteins called lysine methyltransferases, which are enzymes that play a key role in the modification of histone proteins. Histones are proteins that help package and organize DNA in the nucleus of a cell, and modifications to these proteins can have profound effects on gene expression. Studies have shown that KMT5C specifically targets histone H4 lysine 20 (H4K20) for methylation, which has been linked to the regulation of gene transcription and DNA replication. Dysregulation of this process has been implicated in various diseases, including cancer and developmental disorders. In cancer, aberrant expression of KMT5C has been observed in several tumor types, and its overexpression has been associated with poor prognosis. Mutations in the KMT5C gene have been linked to developmental disorders, such as intellectual disability and autism spectrum disorders. These findings highlight the importance of KMT5C in brain development and function, and provide new insights into the underlying mechanisms of these conditions.

Western blot: 1:500-1:1000, Flow cytometry: 1:10-1:50 per million cells in 0.1ml

Q86Y97

Human, Mouse

A portion of amino acids 195-220 from the human protein was used as the immunogen for the KMT5C antibody.

WB, FACS

Purified

This KMT5C antibody is available for research use only.

Aliquot the KMT5C antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

In 1X PBS, pH 7.4, with 0.09% sodium azide

The stated application concentrations are suggested starting points. Titration of the KMT5C antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Flow cytometry testing of fixed and permeabilized human HEK293 cells with KMT5C antibody; Blue=isotype control, Green= KMT5C antibody.