KPNA2 Antilichaam

KPNA2 Antibody: Karyopherin, a cytosolic and heterodimeric protein complex consisting of alpha and beta subunits, is responsible for targeting proteins with nuclear localization signals to the nuclear pore complex by an energy requiring, Ran-dependent mechanism. The alpha subunit and imported substrate enter the nucleus and accumulate in the nucleoplasm, while the beta subunit accumulates at the NPC. KPNA2 is the alpha subunit 2 of karyopherin, which forms a complex with importin subunit beta-1 and functions as a cargo carrier that transports various complexes from cytoplasm into nucleus. It is ubiquitously expressed and contains an IBB/importin beta domain, ten Armadillo repeats that bind "cargo" and three intervening nuclear localization sequences (NLSs) . It has recently been reported to play an important role in tumorigenesis and tumor progression.

3838

P52292

NP_002257

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Cancer, Cell Cycle

KPNA2 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1461 - Rat Heart Tissue Lysate

1 mg/mL

KPNA2 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

KPNA2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

KPNA2

Cat. No. 10-501 - Human Heart Tissue Slide

Cat. No. 1224 – Daudi Cell Lysate

Karyopherin alpha 2 (RAG cohort 1, importin alpha 1)

Homo sapiens

Moroianu J. Molecular mechanisms of nuclear protein transport. Crit. Rev. Eukaryot. Gene Expr.1997; 7:61-72.

Gilchrist D and Rexach M. Molecular basis for the rapid dissociation of nuclear localization signals from karyopherin alpha in the nucleoplasm. J. Biol. Chem.2003; 278: 51937-49.

Tseng SF, Chang CY, Wu KJ, et al. Importin KPNA2 is required for proper nuclear localization and multiple functions of NBS1. J. Biol. Chem.2005; 280:39594-600.

Sakai M, Sohda M, Miyazaki T, et al. Significance of karyopherin-{alpha} 2 (KPNA2) expression in esophageal squamous cell carcinoma. Anticancer Res.2010; 30:851-6.

KPNA2 Antibody: QIP2, RCH1, IPOA1, SRP1alpha, SRP1, Importin subunit alpha-1, Karyopherin subunit alpha-2

ELISA, WB, IHC-P, IF

4504897

Liquid