KPNA2 Antilichaam

The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V (D) J recombination. Alternative splicing results in multiple transcript variants.

3838

P52292

Human, Mouse

Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human KPNA2 (NP_002257.1) .

Unconjugated

Primary Antibodies

Immunology, Signal Transduction

Affinity purification

MCF7

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 55kDa

IgG

KPNA2

PC-3

U-251MG

Mouse testis

Karyopherin alpha 2 (RAG cohort 1, importin alpha 1)

Homo sapiens

KPNA2 Antibody: QIP2, RCH1, IPOA1, SRP1alpha, SRP1, Importin subunit alpha-1, Karyopherin subunit alpha-2

WB, IF, IP

Liquid