KPNA5 Antilichaam

KPNA5 Antibody: Karyopherin, a cytosolic and heterodimeric protein complex consisting of alpha and beta subunits, is responsible for targeting proteins with nuclear localization signals to the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. The alpha subunit and imported substrate enter the nucleus and accumulate in the nucleoplasm, while the beta subunit accumulates at the NPC. KPNA5 belongs to a subfamily within the KPNA family that also includes KPNA4 and 6 and is thought to be involved in NLS-dependent protein import into the nucleus.

3841

O15131

CAH71948

Human

Unconjugated

Primary Antibodies

Homeostasis

KPNA5 Antibody is affinity chromatography purified via peptide column.

Cat. No. 11-701 - Human Testis Tissue Slide

1 mg/mL

Predicted species reactivity based on immunogen sequence: Rat: (81%)

KPNA5 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

KPNA5 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

KPNA5 antibody is human specific. KPNA5 antibody is predicted to not cross-react with other Importin alpha family members.

KPNA5

Karyopherin alpha 5 (importin alpha 6)

Homo sapiens

Moroianu J. Molecular mechanisms of nuclear protein transport. Crit. Rev. Eukaryot. Gene. Expr. 1997; 7:61-72.

Gilchrist D and Rexach M. Molecular basis for the rapid dissociation of nuclear localization signals from karyopherin alpha in the nucleoplasm. J. Biol. Chem. 2003; 278: 51937-49.

Kohler MC, Fiebeler M, Hartwig S, et al. Evidence for distinct substrate specificity of importin alpha family members in nuclear protein import. Mol. Cell. Biol. 1999; 19:7782-91.

KPNA5 Antibody: SRP6, IPOA6, Importin subunit alpha-6, Karyopherin subunit alpha-5

ELISA, IHC-P

55664992

Liquid