KREMEN1 Antilichaam

KREMEN1 Antibody: Kremen (Kringle containing protein marking the eye and the nose) proteins are type I transmembrane proteins that contain extracellular kringle, WSC and CUB domains and an intracellular region without any conserved motifs. Kremens bind a subset of the secreted Dickkopf proteins (Dkk 1, 2, and 4) with high affinity to modulate the canonical Wnt signaling pathway that is transduced by the ternary receptor complex composed of Wnt, Frizzled, and the LDL receptor related protein 5/6 (LRP5/6) coreceptor. KREMEN1 is a receptor for the Dickkopf protein which blocks Wnt/beta catenin signaling. It is necessary to ensure normal spatial and temporal patterns of Wnt activity during developmental processes.

83999

Q96MU8

NP_114434

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Signal Transduction

KREMEN1 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1468 - Rat Small Intestine Tissue Lysate

1 mg/mL

KREMEN1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

KREMEN1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

54 kDa

IgG

Three isoforms of KREMEN1 exists as a result of alternative splicing event.

KREMEN1

Cat. No. 11-801 - Human Small Intestine Tissue Slide

Kringle containing transmembrane protein 1

Homo sapiens

Nakamura T, Aoki S, Kitajima K, et al. Molecular cloning and characterization of Kremen, a novel kringle-containing transmembrane protein. Biochim. Biophys. Acta. 2001; 1518:63-72.

Mao B, Wu W, Davidson G, et al. Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling. Nature 2002; 417:664-7.

Li J, Liu WM, Cao YJ, et al. Roles of Dickkopf-1 and its receptor Kremen1 during embryonic implantation in mice. Fertil. Steril. 2008; 90:1470-9.

Wang K, Zhang Y, Li X, et al. Characterization of the Kremen-binding site on Dkk1 and elucidation of the role of Kremen in Dkk-mediated Wnt antagonism. J. Biol. Chem. 2008; 283:23371-5.

KREMEN1 Antibody: KRM1, KREMEN, KRM1, Kremen protein 1, Dickkopf receptor

ELISA, WB, IHC-P, IF

24041012

Liquid