KREMEN2 Antilichaam

KREMEN2 Antibody: Kremen (Kringle containing protein marking the eye and the nose) proteins are type I transmembrane proteins that contain extracellular kringle, WSC and CUB domains and an intracellular region without any conserved motifs. Kremens bind a subset of the secreted Dickkopf proteins (Dkk 1, 2, and 4) with high affinity to modulate the canonical Wnt signaling pathway that is transduced by the ternary receptor complex composed of Wnt, Frizzled, and the LDL receptor related protein 5/6 (LRP5/6) co-receptor. Recent experiments have shown that KREMEN2 is a regulator of bone remodeling and raise the possibility that antagonizing KREMEN2 might prove beneficial in patients with bone loss disorders.

79412

Q8NCW0

NP_757384

Human, Mouse, Rat

7263

Unconjugated

Primary Antibodies

Independent Antibody Validation in Cell lines (Figure 1) shows similar KREMEN2 expression profile in human, mouse and rat cell lines detected by two independent anti-KREMEN2 antibodies that recognize different epitopes, 7263 against C-terminus domain and 64-235 against central domain. KREMEN2 proteins are detected in most of the tested cell lines at different expression levels by the two independent antibodies. Independent Antibody Validation in Cell lines7263 64-235

Stem Cell

KREMEN2 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1201 - HeLa Cell Lysate

1 mg/mL

KREMEN2 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

KREMEN2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

Multiple isoforms of KREMEN2 are known to exist. KREMEN2 antibody is predicted to not cross-react with other Kremen protein family members.

Human KREMEN2 has 6 isoforms, including isoform 1 (462aa, 49kD), isoform 2 (424aa, 45kD), isoform 3 (420aa, 44kD), isoform 4 (399aa, 42kD), isoform 5 (423aa, 45kD), and isoform 6 (381aa, 40kD) . Mouse KREMEN2 has one isoform (461aa, 49kD) and rat KREMEN2 also has one isoform (468aa, 50kD) . 7263 can detect human, mouse and rat.

KREMEN2

Cat. No. 17-001 - HeLa Cell Slide

Kringle containing transmembrane protein 2

Homo sapiens

Nakamura et al. Biochim. Biophys. Acta. 2001; 1518:63-72.

Mao et al. Nature 2002; 417:664-7.

Li et al. Fertil. Steril. 2008; 90:1470-9.

Schulze et al. PLoS 2010; 5:e10309.

KREMEN2 Antibody: KRM2, KRM2, Kremen protein 2, Dickkopf receptor 2

ELISA, WB, ICC

27437008

Liquid