KSHVORF62 Antilichaam [5B7B6]

Kaposi's sarcoma-associated herpesvirus (KSHV) belongs to the gamma- (2) -herpesvirus subfamily and has been closely linked to the Kaposi’s sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman’s disease. The genome of KSHV is 165-170 kb and contains at least 88 open reading frames. At least five major proteins are likely to be involved in the assembly of the HHV-8 capsid, including a protease (encoded by ORF17), the major capsid protein (encoded by ORF25), and three other smaller capsid proteins (encoded by ORF62, ORF26, and ORF65) . Previous structural studies have shown that the HSV-1 triplex is a monomer of VP19c and a dimer of VP23 and that the HCMV triplex is similarly composed of a monomer and a dimer. By analogy, the KSHV triplexes are likely also composed of a monomer of the ORF62 protein and a dimer of the ORF26 protein, which are the respective homologs of VP19c and VP23.

4961461

F5H8Y5

F5H8Y5

Virus

Ni-NTA purified recombinant human KSHV ORF62 expressed in E. Coli strain BL21 (DE3) .

5B7B6

Unconjugated

Primary Antibodies

Infectious Disease

Batch dependent

Ascitic fluid containing 0.03% sodium azide.

None

Blue Ice

To KSHV ORF62 monoclonal antibody can be stored at -20˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgM

ORF62

Capsid triplex protein

Human herpesvirus 8

Chang Y. et al. 1994. Science. 266:1865-1869.

Russo J.J. et al. 1996. PNAS. 93: 14862-14867.

Wu L. et al. 2000. J VirolOct; 74 (20) :9646-54.

Triplex capsid protein VP19C homolog

WB

550600169