KT2-962
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
KT2-962 is a thromboxane A2 (TXA2) receptor antagonist and potent hydroxyl radical scavenger (IC50=500 nM) . KT2-962 reduces myocardial infarct size and ventricular fibrillation. KT2-962 demonstrates cardioprotective effect in a canine ischemia/reperfusion model. KT2-962 is promising for research of myocardial ischemia-reperfusion injury and TXA2-mediated vascular diseases[1].
129648-96-0
12352005
Prostaglandin Receptor
GPCR/G Protein
Cardiovascular Disease
O=S(C1=C2C=CC(C(C)C)=CC=C2C(CCCCNS(=O)(C3=CC=C(C=C3)Cl)=O)=C1)(O[Na])=O
C23H25ClNNaO5S2
518.02
[1]Ge ZD, et al. Comparison of cardioprotective efficacy of two thromboxane A2 receptor antagonists. J Cardiovasc Pharmacol. 2003 Mar;41 (3) :481-8.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-19129/
Reference compound1
Phase 1
TXA2/TP
Beschrijving
KT2-962 is a thromboxane A2 (TXA2) receptor antagonist and potent hydroxyl radical scavenger (IC50=500 nM) . KT2-962 reduces myocardial infarct size and ventric
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