Kv1.2 Antilichaam, Kloon C25: RPE

Kv1.2, encoded by the KCNA2 gene, is a voltage-gated potassium channel subunit that plays a critical role in regulating neuronal excitability and synaptic transmission. Beyond its significance as a biophysical model for ion channel gating, Kv1.2 has emerged as a key modulator of brain function, with growing evidence linking KCNA2 mutations to a range of neurological disorders, including epilepsy, ataxia, and neurodevelopmental syndromes. A landmark crystallographic study resolved the Kv1.2 channel structure at 2.9 Å, revealing the open activation gate and tetrameric subunit architecture. This structural insight has become foundational for understanding the gating mechanisms of voltage-gated ion channels across the nervous system. Functionally, Kv1.2 channels are expressed in axons and presynaptic terminals, where they shape action potential propagation and modulate neurotransmitter release. By influencing both the timing and strength of synaptic communication, Kv1.2 contributes to the fine-tuning of neural circuit dynamics essential for cognition, motor control, and sensory processing. In the context of neurodegenerative disease, dysregulation of Kv1.2 activity may lead to aberrant neuronal firing, excitotoxicity, and impaired network stability—hallmarks of conditions such as Alzheimer’s disease and multiple sclerosis. As such, Kv1.2 is increasingly recognized as a potential therapeutic target for restoring electrical balance in diseased neural circuits. Due to its recombinant nature, our Human Kv1.2 Recombinant Monoclonal IgG offers high specificity and reproducibility, making it ideal for applications in immunohistochemistry, western blotting, and ion channel research.

Rabbit Anti-Human Kv1.2 Recombinant Monoclonal IgG Kappa

Kv1.2, KCNA2, Potassium voltage-gated channel subfamily A member 2, Voltage-gated potassium channel subunit Kv1.2, NGK1, HBK5, HUKIV, MK2, RBK2, Kca12

12352203

Non-hazardous

Non-hazardous

3737

P16389

NP_004965.1

Fusion protein, AA #428-499 (cytoplasmic C-terminus) of human Kv1.2. Epitope mapped to within AA #463-480 (EGVNNSNEDFREENLKTA) .

C25

RPE

Brain cortex, paranodal and juxtanodal zones in myelinated spinal cord, and peroneal nerve in the juxtaparanodal regions of the nodes of Ranvier.

Recombinant Monoclonal

WB | IHC | ICC/IF

Neuroscience | Ion Channels | Potassium Channels | Voltage-Gated Potassium Channels

AmMagTM Ultra AT Protein A MagBeads

1 µg/ml was sufficient for detection of Kv1.2 in Rat Brain Membrane lysate.

1mg/mL

WB (1:1000), IHC (1:100), ICC/IF (1:100) ; optimal dilutions for assays should be determined by the user.; optimal dilutions for assays should be determined by the user.

95.46mM Phosphate, 2.48mM MES and 2mM EDTA

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Blue Ice or 4ºC

Conjugated antibodies should be stored according to the product label

https://www.stressmarq.com/wp-content/uploads/Antibody-MSDS.pdf

Detects the cytoplasmic C-terminus of Kv1.2. Does not cross-react with other Kv1 channels.

1. Baronas, V. A., Yang, R. Y., & Kurata, H. T. (2017) . Extracellular redox sensitivity of Kv1.2 potassium channels. Scientific Reports, 7, 9145. https://doi.org/10.1038/s41598-017-08718-z 2. Long, S. B., Campbell, E. B., & MacKinnon, R. (2005) . Crystal structure of a mammalian voltage-dependent Shaker family K+ channel. Science, 309 (5736), 897–903. DOI: 10.1126/science.1116269 3. Kole, M. H. P., Letzkus, J. J., & Stuart, G. J. (2007) . Axon initial segment Kv1 channels control axonal action potential waveform and synaptic efficacy. Neuron, 55 (4), 633–647. DOI: 10.1016/j.neuron.2007.07.031

Human | Mouse | Rat

Cell membrane, Cell projection, Synapse, Endoplasmic reticulum membrane, Lamellipodium membrane, Synaptosome, Presynaptic membrane, Dendrite, Paranodal septate junction

IgG Kappa

Human