Kv1.3 Antilichaam, Kloon CAR1.1: ATTO 488

Kv1.3 (KCNA3) is a voltage-gated potassium channel primarily known for its role in regulating membrane potential and cellular excitability. While extensively studied in immune cells, Kv1.3 is also expressed in neurons, microglia, and astrocytes, where it contributes to neuroimmune signaling and homeostatic regulation in the central nervous system. In the context of neurodegenerative disease, Kv1.3 has emerged as a critical modulator of neuroinflammation. Its upregulation in activated microglia has been observed in Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis, where it promotes pro-inflammatory cytokine release, oxidative stress, and neuronal injury. Kv1.3 activity influences calcium signaling and mitochondrial function—two key pathways implicated in neuronal vulnerability and degeneration. Pharmacological inhibition of Kv1.3 has shown promise in preclinical models, reducing microglial activation, preserving synaptic integrity, and improving cognitive outcomes. These findings position Kv1.3 as a potential therapeutic target for modulating neuroinflammatory responses and slowing disease progression. Beyond inflammation, Kv1.3 may also influence neuronal excitability and synaptic plasticity, suggesting broader roles in learning, memory, and neurodegenerative pathophysiology. Its dual presence in immune and neural cells makes Kv1.3 a unique molecular bridge between the immune system and the brain. As interest grows in ion channel-targeted therapies, Kv1.3 stands out as a promising candidate for intervention in neurodegenerative disorders characterized by chronic inflammation and neuronal loss.

Rabbit Anti-Rat Kv1.3 Recombinant Monoclonal IgG Kappa

Kv1.3, KCNA3, KCNA 3, Potassium voltage-gated channel subfamily A member 3, Voltage-gated potassium channel subunit Kv1.3, Voltage-gated potassium channel subunit Kv3, Voltage-gated K (+) channel, HGK5, HLK3, HPCN3, HuKIII, RCK3, RGK5

12352203

Non-hazardous

Non-hazardous

29731

P15384

NP_062143.3

Synthetic peptide, AA #485-506 (cytoplasmic C-terminus) of Rat Kv1.3.

CAR1.1

ATTO 488

Brain, Thymus, Spleen, Ileum, Lung, Testis, Small Intestine, Heart, Colon, Stomach, Esophagus

Recombinant Monoclonal

WB | IHC | ICC/IF

Neuroscience | Ion Channels | Potassium Channels | Voltage-Gated Potassium Channels | Cell Signaling | Cancer

AmMagTM Ultra AT Protein A MagBeads

1 µg/ml was sufficient for detection of Kv1.3 on Rat Brain Membrane lysate.

1mg/mL

WB (1:1000), IHC (1:100), ICC/IF (1:100) ; optimal dilutions for assays should be determined by the user.; optimal dilutions for assays should be determined by the user.

640.91mM DMSO, 136.36 mM Ethanolamine, 126.89 mM chlorides, 9.09mM phosphates, 9.09mM NaHCO3

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Blue Ice or 4ºC

Conjugated antibodies should be stored according to the product label

https://www.stressmarq.com/wp-content/uploads/Antibody-MSDS.pdf

Detects region of v1.3 containing the cytoplasmic C-terminus

1. Pan, Y., Sun, J., Deveson, D., Mamo, J. C. L., Takechi, R., Norton, R., Jin, L., & Nicolazzo, J. (2022) . A transcriptomic study reveals beneficial effects of HsTX1 [R14A] on the cognition of a mouse model of sporadic Alzheimer’s disease. Alzheimer's & Demen-tia. DOI: 10.1002/alz.068693 2. Sarkar, S., Nguyen, H. M., Malovic, E., Luo, J., Langley, M., Pal-anisamy, B. N., Singh, N., Manne, S., Neal, M., Gabrielle, M., Abdalla, A., Anantharam, P., Rokad, D., Panicker, N., Singh, V., Ay, M., Charli, A., Harischandra, D., Jin, L.-W., Jin, H., Rangaraju, S., Anantharam, V., Wulff, H., & Kanthasamy, A. G. (2020) . Kv1.3 modulates neuroinflammation and neurodegeneration in Parkinson’s disease. Journal of Clinical Investigation, 130 (8), 4195–4212. DOI: 10.1172/JCI136174 3. Beraldo-Neto, E., Ferreira, V. F., Vigerelli, H., Fernandes, K. R., Juliano, M. A., Nencioni, A. L. A., & Pimenta, D. C. (2024) . Un-raveling neuroprotection with Kv1.3 potassium channel block-ade by a scorpion venom peptide. Scientific Reports. DOI: 10.1038/s41598-024-79152-1

Human | Mouse | Rat

Cell Membrane

IgG Kappa

Rat