KW-2450 (tosylaat)
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
KW-2450 tosylate is an orally active Aurora A and B kinases, IGF-1R, and IR tyrosine kinases inhibitor. KW-2450 tosylate induces Apoptosis. KW-2450 tosylate also exhibits anticancer activity against triple-negative breast cancer[1].
1360433-93-7
12352005
Apoptosis; Aurora Kinase; IGF-1R
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Protein Tyrosine Kinase/RTK
Cancer
OCC(N(CC1)CCN1CC2=CC(NC(C3=C(C)C=CS3)=O)=C(/C=C/C4=NNC5=C4C=CC=C5)C=C2)=O.CC6=CC=C(S(=O)(O)=O)C=C6
C35H37N5O6S2
687.83
[1]Kai K, et al. Antitumor Activity of KW-2450 against Triple-Negative Breast Cancer by Inhibiting Aurora A and B Kinases. Mol Cancer Ther. 2015 Dec;14 (12) :2687-99.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-19565/
Reference compound1
Phase 2
Beschrijving
KW-2450 tosylate is an orally active Aurora A and B kinases, IGF-1R, and IR tyrosine kinases inhibitor. KW-2450 tosylate induces Apoptosis. KW-2450 tosylate als
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