L-2-Hydroxyglutaarzuur-d5 (dinatrium)

L-2-Hydroxyglutaric acid-d5 disodium ((2S) -2-Hydroxyglutaric acid-d5 disodium) is the deuterium labeled L-2-Hydroxyglutaric acid disodium. L-2-Hydroxyglutaric acid disodium is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid disodium can inhibit histone demethylases and hence promote histone methylation[1]. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity with Km and Ki of 2.52 mM and 11.13 mM, respectively[2].

(2S) -2-Hydroxyglutaric acid-d5 (disodium)

12352211

Endogenous Metabolite; Histone Demethylase; Isotope-Labeled Compounds; Mitochondrial Metabolism

Epigenetics; Metabolic Enzyme/Protease; Others

Cancer

O=C(O[Na])C([2H])(C([2H])([C@](O)(C(O[Na])=O)[2H])[2H])[2H]

C5HD5Na2O5

197.11

[1]Shim EH, et al. L-2-Hydroxyglutarate: an epigenetic modifier and putative oncometabolite in renal cancer. Cancer Discov. 2014 Nov;4 (11) :1290-8.|[2]da Silva CG, et al. L-2-hydroxyglutaric acid inhibits mitochondrial creatine kinase activity from cerebellum of developing rats. Int J Dev Neurosci. 2003 Jun;21 (4) :217-24.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W744986/

Isotope-Labeled Compounds

No Development Reported