L1CAM Mouse Monoclonal Antibody [Kloon ID: LBI10C12]

The protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause three X-linked neurological syndromes known by the acronym CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus) . Alternative splicing of a neuron-specific exon is thought to be functionally relevant.

Carrier-free (BSA/glycerol-free) L1CAM mouse monoclonal antibody, clone LBI10C12

CAML1; CD171; HSAS; HSAS1; MASA; MIC5; N-CAM-L1; N-CAML1; NCAM-L1; S10; SPG1

Homo sapiens L1 cell adhesion molecule (L1CAM), transcript variant 1, mRNA.

3897

P32004

Unconjugated

Axon guidance, Cell adhesion molecules (CAMs)

Axon guidance, Cell adhesion molecules (CAMs)

WB 1:500~1000, IHC 1:50, FLOW 1:100, IP 2-4ug/mg

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Druggable Genome, ES Cell Differentiation/IPS, Transmembrane

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

L1CAM

https://www.ncbi.nlm.nih.gov/gene/?term=3897

https://www.uniprot.org/uniprot/P32004