LA-419

LA-419 is an orally active nitric oxide (NO) donor. LA-419 can significantly reduce the amount of fecal worm eggs excreted, shorten the duration of egg excretion, and also decrease the number of larvae in the lungs and the number of parasitic females in the intestines in mice infected with S. venezuelensis. LA-419 can reduce the formation of atherosclerosis in apolipoprotein E-deficient mice. LA-419 can be used for the researches of infection and cardiovascular disease[1].

263754-93-4

12352005

H315-H319-H335

NO Synthase

Immunology/Inflammation

Infection; Cardiovascular Disease

[H][C@]12[C@]([C@@H](SC(C)=O)CO2)([H])OC[C@H]1O[N+]([O-])=O

C8H11NO6S

249.24

P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501

[1]Ruano AL, et al. Treatment with nitric oxide donors diminishes hyperinfection by Strongyloides venezuelensis in mice treated with dexamethasone. Acta Trop. 2015 Dec;152:90-95.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-19392/

Reference compound2

No Development Reported