Laccaridion B

Laccaridione B can inhibit the activity of antiserine protease. Laccaridione B inhibits trypsin, papain, thermophilic protease, collagenase and zinc protease with IC50s of 10.9 μg/mL, 5.1 μg/mL, 8.4 μg/mL, 5.7 μg/mL and 3.0 μg/mL, respectively. Laccaridione B also has a strong anti-proliferative activity against L-929, K-562 and HeLa cells with IC50s of 2.4 μg/mL, 1.8 μg/mL and 13.9 μg/mL, respectively[1].

320369-81-1

12352005

Ser/Thr Protease

Metabolic Enzyme/Protease

Cancer; Infection

CCOC1C2=C(C=C(O1)/C(C)=C/C(C)CC)C=C3C(C(C(C(OC)=C3)=O)=O)=C2O

C23H26O6

398.45

[1]Barbara Falkensammer, et al. Basidiomycete metabolites attenuate virulence properties of Candida albicans in vitro. Mycoses. 2008 Nov;51 (6) :505-14.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-N14773/

Natural Products

No Development Reported