Lacidipine-d10

Lacidipine-d10 is the deuterium labeled Lacidipine. Lacidipine (Lacipil, Motens) is a L-type calcium channel blocker[1][2].

1185245-62-8

12352005

Apoptosis; Calcium Channel; Isotope-Labeled Compounds; Reactive Oxygen Species (ROS)

Apoptosis; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB; Others

Neuroscience-Neurodegeneration

Cardiovascular Disease

10 mM in DMSO

C(OC(C([2H])([2H])[2H])([2H])[2H])(=O)C=1C(C(C(OC(C([2H])([2H])[2H])([2H])[2H])=O)=C(C)NC1C)C2=C(C=CC(OC(C)(C)C)=O)C=CC=C2

C26H23D10NO6

465.60

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Zhang, A., et al., Lacidipine attenuates apoptosis via a caspase-3 dependent pathway in human kidney cells. Cell Physiol Biochem, 2013. 32 (4) : p. 1040-9.|[3]van Amsterdam, F.T., et al., Lacidipine: a dihydropyridine calcium antagonist with antioxidant activity. Free Radic Biol Med, 1992. 12 (3) : p. 183-7.|[4]Kamal, S.M., Possible hepatoprotective effects of lacidipine in irradiated DOCA-salt hypertensive albino rats. Pak J Biol Sci, 2013. 16 (21) : p. 1353-7.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-B0347S/

Isotope-Labeled Compounds

No Development Reported