Lactaat (natrium) -13C2

Lactic acid-13C2 (DL-Lactic acid-13C2) sodium is the 13C-labeled Lactic acid sodium . Lactic acid (DL-Lactic acid) sodium is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Lactic acid sodium is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Lactic acid sodium is an oncometabolite and has immune protective role of lactate in anti-tumor immunity[1][2]. Lactic acid sodium also has antimicrobial activity, which can be used as a food preservative[3].

1173021-18-5

Lactic acid (sodium) -13C2

12352211

Bacterial; Endogenous Metabolite; Hydroxycarboxylic Acid Receptor (HCAR) ; Isotope-Labeled Compounds

Anti-infection; GPCR/G Protein; Metabolic Enzyme/Protease; Others

Metabolism-sugar/lipid metabolism

Cancer

[13CH3][13C]([H])(C(O[Na])=O)O

C 13C2H5NaO3

114.05

[1]Lucia Longhitano, et al. Lactate Rewrites the Metabolic Reprogramming of Uveal Melanoma Cells and Induces Quiescence Phenotype. Int J Mol Sci. 2022 Dec 20;24 (1) :24.|[2]Qiang Feng, et al. Lactate increases stemness of CD8 + T cells to augment anti-tumor immunity. Nat Commun. 2022 Sep 6;13 (1) :4981. |[3]Sallam KI. Antimicrobial and antioxidant effects of sodium acetate, sodium lactate, and sodium citrate in refrigerated sliced salmon. Food Control. 2007 May;18 (5) :566-575.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W769991/

Isotope-Labeled Compounds

No Development Reported