Lactoquinomycine B

Lactoquinomycin B is a quinone antibiotic. Lactoquinomycin B has the activity of anti-Gram-positive bacteria and some Gram-negative bacteria, but the effect of anti-Gram-negative bacteria is weak and has no effect on fungi. Lactoquinomycin B inhibits a variety of cell lines including lymphoma L5178Y progenitor, Adriamycin resistant, Bleomycin-resistant, human leukemia K562, mouse leukemia L-1210 and mouse leukemia P 388 with ID50 (μg/mL) of 0.43, 0.21, 0.19, 0.16, 0.2 and 0.12, respectively[1].

101342-94-3

12352005

Antibiotic; Bacterial

Anti-infection

Infection

O=C1C23C(C(C4=C(O)C([C@H]5C[C@H]([C@@H]([C@H](O5)C)O)N(C)C)=CC=C41)=O)(C(OC6([H])C3([H])OC(C6)=O)C)O2

C24H27NO9

473.47

[1]T Okabe, et al. Lactoquinomycin B, a novel antibiotic. J Antibiot (Tokyo) . 1986 Jan;39 (1) :1-5.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-N14774/

Natural Products

No Development Reported