LAG-1 (CCL4L1)

LAG-1 is CC chemokine that signals through the CCR5 receptor. LAG-1 is identical to MIP-1beta (ACT II isotype) except for two amino acid substitutions; arginine for histidine at position 22 and serine for glycine at position 47 of the mature protein. LAG-1 chemoattracts monocytes, and exhibits activity as an HIV suppressive factor. Recombinant human LAG-1 is a 7.7 kDa protein containing 69 amino acid residues.

CCL4L1; LAG1; CCL4L; LAG-1; SCYA4L; AT744.2

9560

P13236

NP_001001435

NM_001001435

100-234

Human

Human

APMGSDPPTA CCFSYTARKL PRNFVVDYYE TSSLCSQPAV VFQTKRSKQV CADPSESWVQ EYVYDLELN

< 0.1 ng/µg of protein (< 1EU/µg)

> 90% by SDS-PAGE & HPLC analyses

Determined by it's ability to chemoattract CCR5 transfected cells using a concentration of 0.1-10.0 ng/ml

69

Lyophilized

7.7 kDa

E. coli