LAG-3, Cynomolgus (gebiotinyleerd, HEK293, His-Avi)

LAG-3 Protein, expressed on antigen-activated T-cells, delivers inhibitory signals by binding to ligands like FGL1. LAG-3 Protein associates with CD3-TCR, directly inhibiting T-cell activation[1][2]. LAG-3 Protein, Cynomolgus (Biotinylated, HEK293, His-Avi) is the recombinant cynomolgus-derived LAG-3 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of LAG-3 Protein, Cynomolgus (Biotinylated, HEK293, His-Avi) is 432 a.a., with molecular weight of 60-80 kDa.

LAG-3 Protein, Cynomolgus (Biotinylated, HEK293, His-Avi), Cynomolgus, HEK293

12352202

102122272 (Gene_ID) XP_005570011.1 (A18-H449) (Accession)

60-80 kDa

[1]Luisa Chocarro, et al. Understanding LAG-3 Signaling. Int J Mol Sci. 2021 May; 22 (10) : 5282.|[2]Jun Wang, et al. Fibrinogen-like Protein 1 Is a Major Immune Inhibitory Ligand of LAG-3. Cell. 2019 Jan 10;176 (1-2) :334-347.e12.|[3]Ruea-Yea Huang, et al. LAG3 and PD1 co-inhibitory molecules collaborate to limit CD8+ T cell signaling and dampen antitumor immunity in a murine ovarian cancer model. Oncotarget. 2015 Sep 29; 6 (29) : 27359–27377.|[4]Smadar Gertel, et al. Lymphocyte activation gene-3 (LAG-3) regulatory T cells: An evolving biomarker for treatment response in autoimmune diseases. Autoimmun Rev. 2022 Jun;21 (6) :103085.|[5]Lawrence P. Andrews, et al. LAG3 (CD223) as a Cancer Immunotherapy Target. Immunol Rev. 2017 Mar; 276 (1) : 80–96.

Room temperature in continental US; may vary elsewhere.

Recombinant Proteins