LAG3 Antilichaam [6B12]

The lymphocyte activation gene-3 (LAG3) is a member of the immunoglobulin superfamily and binds MHC class II with high affinity (1), negatively regulating T-cell function and homeostasis (2) . It is expressed in B, T, and NK cells, monocytes, and dendritic cells (3), and acts to regulate T cell expansion (4) . LAG3 is also an important immune checkpoint protein, with anti-LAG3 antibodies activating T effector cells and affecting regulatory T cell functions. Furthermore LAG3 appears to act in a synergistic fashion with PD-1/PD-L1, suggesting that a dual antibody approach may prove useful in cancer immunotherapy.

3902

P18627

NP_002277

Human

LAG-3 antibody was raised against the extracellular domain of human LAG-3

6B12

Unconjugated

Primary Antibodies

Immunology

LAG-3 Antibody is supplied as protein A purified IgG1.

Cat. No. 1331 - Human Lymphoma Tissue Lysate

1 mg/mL

LAG-3 Antibody is supplied in PBS containing 0.02% sodium azide and 50% glycerol.

None

Blue Ice

LAG-3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG1, k

LAG3

Cat. No. 1306 - Human Spleen Tissue

Lymphocyte activating 3

Homo sapiens

Huard B, Tournier M, Hercend T, et al. Lymphocyte-activation gene 3/major histocompatibility complex class II interaction modulates the antigenic response of CD4+ T lymphocytes. Eur J Immunol 1994; 24:3216–21.

Triebel F. LAG-3: a regulator of T-cell and DC responses and its use in therapeutic vaccination. Trends Immunol 2003; 24:619–22.

Workman CJ, Wang Y, El Kasmi KC, et al. LAG-3 regulates plasmacytoid dendritic cell homeostasis. J Immunol. 2009; 182:1885–91.

Workman CJ, Vignali DA. The CD4-related molecule, LAG-3 (CD223), regulates the expansion of activated T cells. Eur J Immunol 2003; 33:970–9.

LAG3 Antibody: lymphocyte activating 3, LAG-3, CD223

IHC-P, ICC, IF

167614500

Liquid