Lamotrigine-13C7,15N

Lamotrigine-13C7,15N (LTG-13C7,15N) is 13C and 15N labeled Lamotrigine. Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine selectively blocks voltage-gated Na+ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy, ?focal seizure, et al[1][2].

LTG-13C7,15N; BW430C-13C7,15N

12352005

Autophagy; Isotope-Labeled Compounds; Sodium Channel

Autophagy; Membrane Transporter/Ion Channel; Others

Cancer-programmed cell death

Neurological Disease; Cancer

Cl[13C]1=[13C](Cl)[13C](C2=[13C]([15NH2])N=C(N)N=N2)=[13CH][13CH]=[13CH]1

C2 13C7H7Cl2N4 15N

264.03

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]M J Leach, et al. Pharmacological studies on lamotrigine, a novel potential antiepileptic drug: II. Neurochemical studies on the mechanism of action. Epilepsia. Sep-Oct 1986;27 (5) :490-7.|[3]Damianka P Getova, et al. A study of the effects of lamotrigine on mice using two convulsive tests. Folia Med (Plovdiv) . Apr-Jun 2011;53 (2) :57-62.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-B0495S8/

Isotope-Labeled Compounds

No Development Reported