LAMTOR1 Antilichaam

LAMTOR1 is a 161 amino acid membrane protein belonging to the LAMTOR family. It has been identified to interact with and recruit the four Rag GTPases (Rag A-D) to the surface of lysosomes (1) . The mTORC1 kinase complex is a critical component in the regulation of cell growth (2) . As part of the ragulator complex, LAMTOR1 recruits the Rag GTPases and the mTORC1 complex to lysosomes, a key step in activation of the TOR signaling cascade by amino acids (3) . LAMTOR1 may be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes / lysosomes (4) .

55004

Q6IAA8

NP_060377

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Homeostasis

LAMTOR1 antibody is affinity chromatography purified via peptide column.

Cat. No. 1202 - A431 Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (100%)

LAMTOR1 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

LAMTOR1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

LAMTOR1 antibody is human, mouse and rat specific. LAMTOR1 antibody is predicted to not cross-react with other LAMTOR family proteins.

LAMTOR1

Cat. No. 11-801 - Human Small Intestine Tissue Slide

Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1

Homo sapiens

Sancak Y, Bar-Peled L, Zoncu R, et al. Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell 2010; 141:290-303.

Kim E, Goraksha-Hicks P, Li L, et al. Regulation of TORC1 by Rag GTPases in nutrient response. Nat. Cell Biol. 2008; 10:935-45.

Wullschleger S, Loewith R, and Hall MN. TOR signaling in growth and metabolism. Cell 2006; 124:471-84.

Soma-Nagae T, Nada S, Kitagawa M, et al. The lysosomal signaling anchor p18/LAMTOR1 controls epidermal development by regulating lysosome-mediated catabolic processes. J. Cell Sci. 2013; 126:3575-84.

LAMTOR1 Antibody: p18, PDRO, C11orf59, p27RF-Rho, Ragulator1, PP7157, Ragulator complex protein LAMTOR1, Lipid raft adaptor protein p18

ELISA, WB, IHC-P, IF

8923579

Liquid