LAMTOR1 (NM 017907) Humaan Recombinant eiwit

As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation.[UniProtKB/Swiss-Prot Function]

Purified recombinant protein of Human late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 (LAMTOR1), Gly2–Pro161, with N-terminal His-PDCD1 (Pro21-Val170) tag, expressed in E. coli, 50ug

C11orf59; p18; p27RF-Rho; PDRO; Ragulator1

55004

Q6IAA8

NM_017907

11q13.4

E. coli

N-His PDCD1 (Pro21-Val170)

>50 ug/mL as determined by microplate BCA method

> 80% as determined by SDS-PAGE and Coomassie blue staining

Liquid

25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1% Sarkosyl.

34.4 kDa

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

LAMTOR1

Human

NP_060377

https://www.ncbi.nlm.nih.gov/gene/55004

https://www.uniprot.org/uniprot/Q6IAA8

https://www.ncbi.nlm.nih.gov/nuccore/NM_017907

https://www.ncbi.nlm.nih.gov/nuccore/NP_060377