LAMTOR2 Antilichaam

The late endosomal/lysosomal adaptor MAPK and MTOR activator 2 (LAMTOR2) protein belongs to the LAMTOR family of proteins, and together with LAMTOR3 and the MAPK1 and ERK kinase 1 (MEK1) localizes to late endosomes where it is required for the efficient activation of ERK signaling (1,2) . This complex is involved in the regulation of late endosomal traffic and cellular proliferation (3) and plays a role in cellular host defense against Salmonella infection (4) .

28956

Q9Y2Q5

NP_054736

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Homeostasis

LAMTOR2 antibody is affinity chromatography purified via peptide column.

Cat. No. 1211 - HepG2 Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (100%)

LAMTOR2 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

LAMTOR2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

LAMTOR2 antibody is human, mouse and rat reactive. At least two isoforms of LAMTOR2 are known to exist; this antibody will detect both isoforms. LAMTOR2 antibody is predicted to not cross-react with other LAMTOR family proteins.

LAMTOR2

Cat. No. 10-901 - Human Spleen Tissue Slide

Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2

Homo sapiens

Wunderlich W, Fialka I, Teis D, et al. A novel 14-kilodalton protein interacts with the mitogen-activated protein kinase scaffold MP1 on a late endosomal/lysosomal compartment. J. Cell Biol. 2001; 152:765-76.

Teis D, Wunderlich W, and Huber LA. Localization of the MP1-MAPK scaffold complex to endosomes is mediated by p14 and required for signal transduction. Dev. Cell 2002; 3:803-14.

Teis D, Taub N, Kurzbauer R, et al. p14-MP1-MEK1 signaling regulates endosomal traffic and cellular proliferation during tissue homeostasis. J. Cell Biol. 2006; 175:861-8.

Taub N, Nairz M, Hilber D, et al. The late endosomal adaptor p14 is a macrophage host-defense factor against Salmonella infection. J. Cell Sci. 2012; 125:2698-708.

LAMTOR2 Antibody: p14, ENDAP, ROBLD3, HSPC003, MAPBPIP, MAPKSP1AP, Ragulator2, Ragulator complex protein LAMTOR2, Endosomal adaptor protein p14, MAPBP-interacting protein

ELISA, WB, IHC-P, IF

7661728

Liquid