Lapatinib (ditosilaat) (standaard)

Lapatinib (ditosylate) (Standard) is the analytical standard of Lapatinib (ditosylate) . This product is intended for research and analytical applications. Lapatinib ditosylate (GW572016 ditosylate) is a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively[1].

388082-77-7

12352100

Autophagy; EGFR; Ferroptosis; Reference Standards

Apoptosis; Autophagy; JAK/STAT Signaling; Others; Protein Tyrosine Kinase/RTK

Cancer

O=S(CCNCC1=CC=C(C2=CC=C3C(C(NC4=CC(Cl)=C(C=C4)OCC5=CC(F)=CC=C5)=NC=N3)=C2)O1)(C)=O.O=S(C6=CC=C(C)C=C6)(O)=O.O=S(C7=CC=C(C)C=C7)(O)=O

C43H42ClFN4O10S3

925.46

[1]Rusnak DW, et al. The effects of the novel, reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and tumor-derived cell lines in vitro and in vivo. Mol Cancer Ther. 2001 Dec;1 (2) :85-94

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-50898AR/

Reference Standards