LAT2 (SLC7A8) Mouse Monoclonal Antibody [Kloon ID: LBI5A9]

Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re) absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine orD, L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Plays an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney.

Carrier-free (BSA/glycerol-free) SLC7A8 mouse monoclonal antibody, clone LBI5A9

LAT2; LPI-PC1

Homo sapiens solute carrier family 7 member 8 (SLC7A8), transcript variant 1, mRNA.

23428

Q9UHI5

Unconjugated

WB 1:500, IHC 1:50, IF 1:100, FLOW 1:100, IP 2ug/500ul

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Druggable Genome, Transmembrane

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

SLC7A8

https://www.ncbi.nlm.nih.gov/gene/?term=23428

https://www.uniprot.org/uniprot/Q9UHI5